A New Drug Might Deal with Kind 2 Diabetes

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The drug has already been efficiently examined in animal research.

Scientists develop a brand new drug candidate to deal with diabetes.

A novel hormone mixture has been created by a analysis crew from Helmholtz Munich, the German Middle for Diabetes Analysis (DZD), and Novo Nordisk for the potential remedy of kind 2 diabetes sooner or later. The researchers mixed the blood sugar-lowering actions of the medicines tesaglitazar and GLP-1 (Glucagon-like peptide-1) to create a brand new and very efficient drug.

The advantage of combining Tesaglitazar with GLP-1 is that the Tesaglitazar solely penetrates the tissue with GLP-1 receptors. This will increase the consequences on sugar metabolism whereas lessening the unintended effects of tesaglitazar. Scientists have already efficiently examined the brand new drug in animal research. The examine was just lately printed within the journal Nature Metabolism

Tesaglitazar enhances glucose and fats metabolism in kind 2 diabetic sufferers. It will increase insulin sensitivity by appearing on two receptors contained in the cell nucleus. This was demonstrated in section 3 scientific trials. Nonetheless, tesaglitazar has unintended effects equivalent to kidney harm.

GLP 1 Drug

The brand new drug candidate (GLP-1/tesaglitazar) enhanced enhancements of physique weight, meals consumption, and glucose metabolism relative to the GLP-1 or tesaglitazar alone in overweight male mice. Credit score: Helmholtz Munich

Nonetheless, as a way to make the most of the drug therapeutically, the researchers employed a trick: they biochemically mixed tesaglitazar with the gastrointestinal hormone GLP-1. Consequently, the mixed drug can solely work on cells and tissues which have GLP-1 receptors.

“This trick enabled us to mix the blood sugar-reducing results of GLP-1 and tesaglitazar right into a single extremely efficient molecule whereas holding tesaglitazar away from tissues that it might harm,” explains PD Dr. Timo Müller, corresponding creator, director of the Institute of Diabetes and Weight problems, and scientist at DZD.

The brand new drug improves glucose tolerance and sugar metabolism

The brand new drug has already been efficiently examined in animal research: “The sugar metabolism of overweight and diabetic male mice improved to a far larger extent in contrast with remedy utilizing solely the GLP-1 hormone or tesaglitazar alone – and with no damaging hostile results to the liver or kidney,” says Professor Kerstin Stemmer, one of many lead authors of the examine.

The substance was significantly efficient in growing glucose tolerance ranges. Solely minimal doses of the brand new drug have been required to attain sustainable enchancment of glucose metabolism.

“This drug has nice potential for the acute remedy of elevated blood sugar ranges related to kind 2 diabetes,” says Aaron Novikoff, one other lead creator of the examine.

The researchers now need to examine whether or not this drug additionally has the potential to deal with people with kind 2 diabetes and whether or not the efficacy of this new mixture remedy could be optimized additional utilizing biochemical modifications.

Background:

The crew comprised of Professor Dr. Matthias Tschöp (scientific director of Helmholtz Munich), PD Dr. Timo Müller, Richard DiMarchi, Ph.D. (Indiana College), and Dr. Brian Finan (Novo Nordisk) has been working for a few years on new drug candidates for the remedy of kind 2 diabetes and weight problems. Poly-agonists concurrently mimic the consequences of assorted hormones. Medical trials have proven that some poly-agonists are exceptionally promising within the remedy of weight problems and sort 2 diabetes and are already in section 2 and section 3 trials.

This yr within the USA the primary twin agonist drug for the remedy of kind 2 diabetes was authorized. The drug combines GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonists that mimic the consequences of the intestinal hormones GLP-1 and GIP.

Reference: “GLP-1-mediated supply of tesaglitazar improves weight problems and glucose metabolism in male mice” by Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patrick J. Knerr, Konxhe Kulaj, Fanny Lalloyer, Heiko Lickert, Arek Liskiewicz, Daniela Liskiewicz, Gandhari Maity, Diego Perez-Tilve, Sneha Prakash, Miguel A. Sanchez-Garrido, Qian Zhang, Bart Staels, Natalie Krahmer, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, and Timo D. Müller, 22 August 2022, Nature Metabolism.

DOI: 10.1038/s42255-022-00617-6

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